李珊珊-立博体育app官网

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李珊珊

      

李珊珊,女,1984年2月出生于山东省胶州市,副研究员,硕士生导师。研究方向为微生物天然产物农药及其代谢工程。

2006年获西北大学生物工程专业工学学士学位,2009年获西北大学生物化工专业工学硕士学位,2012年获天津大学生物化工专业工学博士学位。2013-2017年在中国科学院微生物研究所进行博士后研究。2017年至今在立博体育app官网植物病虫害生物学国家重点实验室工作,入选青年英才计划”D”类。

李珊珊长期从事微生物天然产物农药的代谢机制及其工程化改造研究,先后主持国家自然科学基金课题3项,以天然产物农药的重要工业生产菌株链霉菌为研究对象,遵循“格物致知—建物致用”的研究思路,解析了胞内三酰甘油动态调节链霉菌农用聚酮类抗生素产生的重要代谢转变机制,并通过建立链霉菌合成生物学必需启动子元件库、链霉菌代谢途径适配策略和菌株高通量筛选方法,构建了多株链霉菌高产菌株,为高效工业化生产天然产物农药提供重要基础。

研究成果以第一或通讯作者在Science Advances, Chemical communications, ACS Synthetic Biology, Microbial Cell Factories等期刊上发表SCI论文10篇,并有2篇研究论文被Chemical communications期刊遴选为Back-Cover亮点文章。申请国家发明专利3项。获得省部级自然发明一等奖1项。

 

联系电话:010-62810155

E-mail: ssli@amanda-cooper.com

 

代表性论文


1、Jiaqian Cao†, Yongpeng Yao†, Keqiang Fan, Gaoyi Tan, Wensheng Xiang, Xuekui Xia, Shanshan Li*, Weishan Wang*, Lixin Zhang*. Harnessing a novel capability of bacterial allosteric transcription factors for sensing diverse small molecules in vitro. Science Advances. 2018; 4 : eaau4602.
2、Shanshan Li†, Junyang Wang†, An Autoregulated Fine-Tuning Strategy for Titer Improvement of Secondary Metabolites Using Native Promoters in Streptomyces. ACS Synthetic Biology. 2018, 7, 522−530.
3、Yongpeng Yao†, Shanshan Li†, Jiaqian Cao, Weiwei Liu, Keqiang Fan, Wensheng Xiang, Keqian Yang*. Development of small molecule biosensors by coupling the recognition of the bacterial allosteric transcription factor with isothermal strand displacement amplification. Chemical Communications. 2018, 54, 4774—4777. (Back-Cover)
4、Yongpeng Yao†, Shanshan Li†, Jiaqian Cao, Weiwei Liu, Fengxian Qi, Wensheng Xiang, Keqian Yang*, Weishan Wang, Lixin Zhang. A novel signal transduction system for the development of uric acid biosensors. Applied Microbiology and Biotechnology. 2018, 102(17):7489-7497.
5、Shanshan Li, Li Zhou, Yongpeng Yao, Keqiang Fan, Zilong Li, Lixin Zhang, Weishan Wang*, and Keqian Yang*. A platform for development of novel biosensors by configuring allosteric transcription factor recognition with amplified luminescence proximity homogeneous assay. Chemical Communications. 2016, 2017,53, 99-102. (Back-Cover)
6、Shanshan Li†, Weishan Wang†, Xiao Li, Keqiang Fan, and Keqian Yang*. Genome-wide identification and characterization of reference genes with different transcript abundances for Streptomyces coelicolor. Scientific Reports. 2015, 5:15840.
7、Shanshan Li†, Junyang Wang†, Xiao Li, Shouliang Yin, Keqiang Fan, WeishanWangF, and Keqian Yang*. Genome-wide identification and evaluation of constitutive promoters in streptomycetes. Microbial Cell Factories. 2015, 14:172.
8、Shanshan Li, Di Huang, Yong Li, Jianping Wen*, and Xiaoqiang Jia. Rational improvement of the engineered isobutanol-producing Bacillus subtilis by elementary mode analysis. Microbial Cell Factories. 2012, 11:101.
9、Shanshan Li, Xiaoqiang Jia, Jianping Wen*. Improved 2-methyl-1-propanol production in an engineered Bacillus subtilis by constructing inducible pathways. Biotechnology Letters. 2012, 34:2253-2258.
10、Shanshan Li, Jianping Wen*, and Xiaoqiang Jia. Engineering Bacillus subtilis for isobutanol production by heterologous Ehrlich pathway construction and the biosynthetic 2-ketoisovalerate precursor pathway overexpression. Applied Microbiology and Biotechnology. 2011, 91:577-589.

 

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